WHAT WE OFFER
· Programs designed exclusively for individual scientists
· Flexible course content tailored to your company and personnel
· Level of presentations determined by your needs
· Up-to-date information
· Expert instruction
· Clear instructional objectives
· Comprehensive written text with each course
· Flexible discussion and problem-solving sessions
HOW YOU BENEFIT
· Guaranteed quality instruction meeting educational objectives
· Minimize your costs: no travel, hotel, per diem or high per attendee instructional costs
· Maximize valuable time away from productive activities
· Course time selected for your convenience
· Confidential discussions about your current scientific problems
COURSE DEVELOPMENT
We will work with one of more members of your Division in order to create the most useful relevant and time-efficient course(s) to meet your organization's needs. Courses typically run all day for two to five days, depending upon the amount and complexity of material to be covered. Several discussion/tutorial or problem-solving sessions are generally provided each day following major topic areas. These workshop sessions are hands-on problem solving and/or extensive focused discussions addressing the material presented. An emphasis, when appropriate, will be given to a discussion of specific problems faced by your Division.
COURSE DESIGN
We recommend that the first one to one and one-half days be devoted to a presentation of principles. Subsequent days will allow development of more specific topic areas that build upon the principles. The background, training and experience of the industrial scientists attending the course will dictate the level of presentation and course organization. Our experience, however, suggest that attendees typically have a wide range of knowledge (from informal exposure to extensive experience). It is primarily for that reason that major benefits are obtained from tailoring the course to the specific needs of your Division.
While limited enrollment offers the greatest opportunity for learning and problem solving, large audiences may benefit from attending certain portions of the course. This type of flexibility can be logistically arranged and built into the course.
COURSE MATERIAL: TOPIC AREAS
The following listings under the general headings of Principles and Applications are topics that have been presented in several previous courses. This list is not exhaustive but is provided to illustrate the range of topic areas that could be presented. A course can be designed in a logical and sequential fashion to include selections of many of the topics noted and others (not noted) of interest to your Division.
PRINCIPLES
· Drug Disposition
· Pharmacokinetic modeling
· Pharmacokinetic data analyses
· Clearance concepts
· Statistical moment theory
· Nonlinearities in absorption and disposition
· Multiple dosing and effective half-life
· Absorption - basic factors
· Bioavailability and bioequivalence
· Physiologically-based pharmacokinetic models
· Pharmacodynamics and pharmacokinetic/pharmacodynamic models
· Kinetics of drug interactions
· Risk assessment
APPLICATIONS
· Absorption-biopharmaceutic and formulation factors
· Special populations: age, gender, renal and hepatic diseases
· Newer and novel dosage forms
· Preclinical pharmacokinetic concerns and issues
· Cytochrome P450 enzymes and P-glycoprotein: in vitro-in vivo correlations
· Cytochrome P450 enzymes: predicting interactions
· Caco II cells for permeability screening
· Statistical issues in bioequivalence testing
· "First-time in human" dosing
· Phases of drug development
· Problems, pitfalls and fatal errors in pharmacokinetic data analyses
· Influence of food on drug absorption
· Influence of disease on drug absorption/disposition
· Influence of route of administration
· Newer modes of administration: pulmonary, nasal, sublingual, colonic
· Issues with dosage forms: sustained release, implant, liposome, depot
· Protein and peptide drugs
WE CAN ALSO ARRANGE
· Special topic courses at national and international venues
· Intense training in data analyses and use of conventional and specialized computer programs
FOR MORE INFORMATION, PLEASE CONTACT:
Michael Mayersohn, Ph.D.
(P) 520-626-1938
(F) 520-626-4063
mayersohn@pharmacy.arizona.edu
Lynne Mascarella
(P) 520-626-3020
(F) 520-626-2023
mascarella@pharmacy.arizona.edu
College of Pharmacy
The University of Arizona
PO Box 210207
Tucson, AZ 85721-0207
