Arishel Inc.
Journal Articles

Kostenbauder, H.B., H.G. Boxenbaum and P.P. DeLuca. Nylon as a dialysis membrane. J. Pharm. Sci. 58: 753757 (1969).

Boxenbaum, H.G., S. Riegelman and R. Elashoff. Statistical estimations in pharmacokinetics. J. Pharmacokin. Biopharm. 2: 123148 (1974).

Boxenbaum, H.G., G. Jodhka, A. Ferguson, S. Riegelman and T. MacGregor. The influence of bacterial gut hydrolysis on the fate of orally administered isonicotinuric acid in man. J. Pharmacokin. Biopharm. 2: 211237 (1974).

Boxenbaum, H.G. and S. Riegelman. Determination of isoniazid and metabolites in biological fluids. J. Pharm. Sci. 63: 11911197 (1974).

Kramer, W.G., R.P. Lewis, T.C. Cobb, J.A. Visconti, L.A. Wanke, H.G. Boxenbaum and R.H. Reuning. Pharmacokinetics of digoxin. Comparison of a two and three compartment model in man. J. Pharmacokin. Biopharm. 2: 299312 (1974).

Boxenbaum, H.G. and S.A. Kaplan. Potential source of error in absorption rate calculations. J. Pharmacokin. Biopharm. 3: 257 264 (1975).

Boxenbaum, H.G., I. Bekersky, V. Mattaliano and S.A. Kaplan. Plasma and salivary concentrations of isoniazid in man: Preliminary findings in two slow acetylator subjects. J. Pharmacokin. Biopharm. 3: 443456 (1975).

Cotler, S., A. Holazo, H.G. Boxenbaum and S.A. Kaplan. Influence of route of administration on physiological availability of levodopa in dogs. J. Pharm. Sci. 65: 822827 (1976).

Boxenbaum, H.G. and S. Riegelman. Pharmacokinetics of isoniazid and some metabolites in man. J. Pharmacokin. Biopharm. 4: 287325 (1976).

Boxenbaum, H.G., J. Fellig, L.S. Hanson, W.E. Snyder and S.A. Kaplan. The absorption, distribution, and elimination of sulfadimethoxine in cattle. Res. Vet. Sci. 23: 2428 (1977).

Boxenbaum, H.G., K.A. Geitner, M.L. Jack, W.R. Dixon, H.E. Spiegel, J. Symington, R. Christian, J.D. Moore, L. Weissman and S.A. Kaplan. Pharmacokinetic and biopharmaceutic profile of chlordiazepoxide HCl in healthy subjects: Single dose studies by the intravenous, intramuscular, and oral routes. J. Pharmacokin. Biopharm. 5: 323 (1977).

Boxenbaum, H.G., K.A. Geitner, M.L. Jack, W.R. Dixon and S.A. Kaplan. Pharmacokinetic and biopharmaceutic profile of chlordiazepoxide HCl in healthy subjects: Multiple dose oral administration. J. Pharmacokin. Biopharm. 5: 2539 (1977).

Boxenbaum H.G. and W. Dairman. Evaluation of an animal model for the screening of compounds potentially useful in human ulcerative colitis: Effect of salicylazosulfapyridine and prednisolone on carrageenaninduced ulceration of the large intestine of the guinea pig. Drug Develop. Industrial Pharm. 3: 121130 (1977).

Eatman, F., W. Colburn, H.G. Boxenbaum, H.N. Posmanter, R.E. Weinfeld, R. Ronfeld, L. Weissman, J.D. Moore, M. Gibaldi and S.A. Kaplan. Pharmacokinetics of diazepam following multiple dose oral administration to subjects. J. Pharmacokin. Biopharm. 5: 481495 (1977).

Eatman, F.B., A.C. Maggio, R. Pocelinko, H.G. Boxenbaum, K.A. Geitner, W. Glover, T. Macasieb, A. Holazo, R.E. Weinfeld and S.A. Kaplan. Blood and salivary concentrations of sulfamethoxazole and trimethoprim in man. J. Pharmacokin. Biopharm. 5: 615624 (1977).

Bekersky, I., A.C. Maggio, V. Mattaliano, Jr., H.G. Boxenbaum, D.E. Maynard, P.D. Cohn and S.A. Kaplan. Influence of phenobarbital on the disposition of clonazepam and antipyrine in the dog. J. Pharmacokin. Biopharm. 5: 507512 (1977).

Bekersky, I., H.G. Boxenbaum, M.H. Whitson, C.V. Puglisi, R. Pocelinko and S.A. Kaplan. Simultaneous determination of salicylic acid and salicyluric acid in plasma and urine by high pressure liquid chromatography. Anal. Letters 10: 539550 (1977).

Wurzburger, R.J., R.L. Miller, H.G. Boxenbaum and S. Spector. Radioimmunoassay of atropine in plasma. J. Pharmacol. Exp. Ther. 203: 435441 (1977).

Boxenbaum, H.G., H.N. Posmanter, T. Macasieb, K.A. Geitner, R.E. Weinfeld, J.D. Moore, A. Darragh, D.A. O'Kelly, L. Weissman and S.A. Kaplan. Single and multiple dose pharmacokinetics of flunitrazepam in healthy human subjects. J. Pharmacokin. Biopharm. 6: 283293 (1978).

Dixon, R., R. Young, E. Mohacsi, A. Holazo, D. Malarek, H. Boxenbaum, J. Moore, M. Parsonnet and S. Kaplan. ()2HydroxyN cyclopropylmethylmorphinan: Radioimmunoassay and pharmacokinetic profile. Clin. Pharmacol. Ther. 24: 622627 (1978).

Boxenbaum, H.G., I. Bekersky, M.L. Jack and S.A. Kaplan. Influence of gut microflora on bioavailability. Drug Metab. Rev. 9: 259279 (1979).

Khoo, KC., J. Mendels, M. Rothbart, W.A. Garland, W.A. Colburn, B.H. Min, R. Lucek, J.J. Carbone, H.G. Boxenbaum and S.A. Kaplan. Influence of phenytoin and phenobarbital on the disposition of a single oral dose of clonazepam. Clin. Pharmacol. Ther. 28: 368 375 (1980).

Boxenbaum, H. Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: Extrapolation of data to benzodiazepines and phenytoin. J. Pharmacokin. Biopharm. 8: 165176 (1980).

Boxenbaum, H. Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics. J. Pharmacokin. Biopharm. 10: 201227 (1982).

Boxenbaum, H. and J.H. Jaffe.  Publication trends in the drug dependence literature.  Am. J. Drug Alcohol Abuse 9: 5568 (1982).

Boxenbaum, H. Comparative pharmacokinetics of benzodiazepines in dog and man. J. Pharmacokin. Biopharm. 10: 411426 (1982).

Boxenbaum, H. Literature growth in pharmacokinetics. J. Pharmacokin. Biopharm. 10: 335348 (1982).

Boxenbaum, H.G. Physiological and pharmacokinetic factors affecting performance of sustained release dosage forms. Drug Develop. Industrial Pharm. 8: 125 (1982); reprinted in Indian J. Pharm. Sci. 45: 113  (1983).

Boxenbaum, H. Evolutionary biology, animal behavior, fourth dimensional space and the raison d'être of drug metabolism and pharmacokinetics. Drug Metab. Rev. 14: 10571097 (1983).

Boxenbaum, H. and R. Ronfeld. Interspecies pharmacokinetic scaling and the Dedrick plots. Am. J. Physiol. 245: R768R775 (1983).

Boxenbaum, H. and J.B. Fertig. Scaling of antipyrine intrinsic clearance of unbound drug in 15 mammalian species. Eur. J. Drug Metab. Pharmacokin. 9: 177183 (1984).

Boxenbaum, H. and D. Ciraulo. Alcoholism and mortality kinetics. J. Pharm. Sci. 73: 11911195 (1984).

Boxenbaum, H. Pharmacokinetic determinants in the design and evaluation of sustainedrelease dosage forms. Pharmaceutical Res. 1: 8288 (1984).

Boxenbaum, H. and J.B. Fertig. Scaling of camptothecin plasma protein binding in 24 species. Biopharm. Drug Disposition 5:405 408 (1984).

Boxenbaum, H. Interspecies pharmacokinetic scaling and the evolutionarycomparative paradigm. Drug Metab. Rev. 15: 10711121 (1984).

Boxenbaum, H. and J. Barnhill. Rates of pharmacokinetic literature obsolescence. Int. J. Pharmaceutics 21: 135141 (1984).

Boxenbaum, H. and F. Pivinski. Frequently cited references in contemporary pharmacokinetics. Drug Metab. Rev. 15: 13851402 (1984-85).

Khor, S.P., H.J. Wu and H. Boxenbaum. Simultaneous correction for volume shifts and protein leakage in equilibrium dialysis protein binding experiments. Int. J. Pharmaceutics 23:109113 (1985).

Ciraulo, D.A., J. Barnhill and H. Boxenbaum. Pharmacokinetic interaction of disulfiram and antidepressants. Am. J. Psychiatry 142: 13731374 (1985).

Boxenbaum, H., C.B. McCullough and F.J. Di Carlo. Mortality kinetics in toxicology studies. Drug Metab. Rev. 16: 321362 (19851986).

Khor, S.P., Wu, H.J. and H. Boxenbaum. Fluid shift and protein leakage corrections in protein binding equilibrium dialysis experiments. Int. J. Pharmaceutics 30: 189197 (1986). 

Ciraulo, D.A., J.G. Barnhill, H.G. Boxenbaum, D.J. Greenblatt & R.B. Smith. Pharmacokinetics and clinical effects of alprazolam in panic disorder patients following single and multiple oral doses. J. Clin. Pharmacol. 26: 292298 (1986). 

Greenblatt, D.J., D.R. Abernethy, H.G. Boxenbaum, R. Matlis, H.R. Ochs, J.S. Harmatz & R.I. Shader. Influence of age, gender, and obesity on salicylate kinetics following single doses of aspirin. Arthritis & Rheumatism 29: 971980 (1986).

Boxenbaum, H.  Time concepts in physics, biology and pharmacokinetics. J. Pharm. Sci. 75: 10531062 (1986).

Boxenbaum, H., F. Pivinski & S. J. Ruberg.  Publication rates of pharmaceutical scientists: Application of the Waring  distribution.  Drug Metab. Rev. 18:553571 (1987). 

Markin, R.S., W.J. Murray & H. Boxenbaum. Quantitative structure activity study of human pharmacokinetic parameters of benzodiazepines using the graph theoretical approach.  Pharmaceutical Res. 5:201208 (1988).

Shumaker, R.C., H. Boxenbaum & G.A. Thompson. ABSPLOTS: A Lotus 123 spreadsheet for calculating drug absorption rates.  Pharmaceutical Res. 5:247248 (1988). 

Boxenbaum, H., Neafsey, P.J. and Fournier, D.J. Hormesis, Gompertz Functions, and Risk Assessment. Drug Metab. Rev. 19:195 229 (1988). 

D'Souza, R.W. & Boxenbaum, H. Physiological pharmacokinetic models: Some aspects of theory, practice and potential. Toxicol. Ind. Health 4: 151171 (1988). 

Hook, R.H., Boxenbaum, H., Thompson, G.A. and Okerholm, R.A. Human serum and plasma protein binding of enoximone and its sulfoxide metabolite. J. Pharm. Sci. 77: 10121017 (1988).

Greenblatt, D.J., Divoll, M.K., Soong, M.H., Boxenbaum, H.G., Harmatz, J.S. & Shader, R.I. Desmethyldiazepam Pharmacokinetics: Studies Following Intravenous and Oral Desmethyldiazepam, Oral Clorazepate, and Intravenous Diazepam.  J. Clin. Pharmacol. 28: 853859 (1988). 

Neafsey, P.J., Boxenbaum, H., Ciraulo, D.A. & Fournier, D.J.  A Gompertz agespecific mortality rate model of aging, hormesis, and toxicity: Fixed dose studies.  Drug Metab. Rev. 19:369401 (1988).

Boxenbaum, H. Commentary to "Linear and nonlinear system approaches in pharmacokinetics: How much do they have to offer? I. General considerations" by P. VengPedersen. J. Pharmacokin. Biopharm. 16:672681 (1988). 

Neafsey, P.J., Boxenbaum, H., Ciraulo, D.A. & Fournier, D.J. A Gompertz agespecific mortality rate model of aging, hormesis, and toxicity: Doseresponse studies. Drug Metab. Rev. 20:111150 (1989). 

Bass, L., Green, H.S. & and Boxenbaum, H. Gompertzian mortality derived from competition between cell types: Congenital, toxicologic and biometric determinants of longevity. J. Theoret. Biol. 140:263278 (1989). 

Neafsey, P.J., Boxenbaum, H., Ciraulo, D.A. & Fournier, D.J.  A Gompertz agespecific mortality rate model of aging: Modification by dietary restriction in rats.  Drug Metab. Rev. 21:351365 (1989). 

Thompson, G.A., Smithers, J. & Boxenbaum, H. Biphasic mortality response of chipmunks in the wild to single doses of ionizing radiation: Toxicity and longevity hormesis. Drug Metab. Rev. 22:269289 (1990).

Boxenbaum, H. It has been said [a special section of the journal devoted to citing interesting quotations]  collected by Harold Boxenbaum. Persp. Biol. Med. 34:275277 (1991). 

Boxenbaum, H. Gompertz mortality analysis: Aging, longevity hormesis and toxicity. Arch. Gerontol. Geriat. 13:125137 (1991).

Boxenbaum, H. Scientific creativity: A review. Drug Metab. Rev. 23:473492 (1991). 

Boxenbaum, H. Pharmacokinetics: Philosophy of Modeling. Drug Metab. Rev. 24:89120(1992). 

Boxenbaum, H., Gillespie, T., Heck, K. and Hahne, W. Human Dolasetron Pharmacokinetics: I. Disposition following single-dose intravenous administration to normal male subjects. Biopharm. Drug Dis. 13:693-701 (1992). 

Boxenbaum, H., Gillespie, T., Heck, K. and Hahne, W. Human dolasetron pharmacokinetics: II. Absorption and disposition following single-dose oral administration to normal male subjects. Biopharm. Drug Dis. 14:131-141 (1993). 

Boxenbaum, H.  Longevity hormesis: Reversible life prolongation from nonessential agents. Comments on Toxicology 5:141-149 (1994).

Boxenbaum, H. & DiLea, C.  First-time-in-human dose selection: Allometric thoughts and perspectives. J. Clin. Pharmacol. 35:957-966 (1995). 

Boxenbaum, H. & Battle, M.  Effective half-life in clinical pharmacology. J. Clin. Pharmacol. 35: 763-766 (1995). 

Tannenbaum, S., Boxenbaum, H. & Mayersohn, M. Allometric analysis of organ extraction ratios. J. Pharm. Sci. 86:1319-1320 (1997). 

Boxenbaum, H. Pharmacokinetic Tricks and Traps: Flip-Flop Models. J. Pharm. Pharmaceut. Sci. (www.ualberta.ca/~csps) 1 (3): 90-91 (1998). 

Boxenbaum, H, Tannenbaum, S, Mayersohn, M., Oleson, F. Pharmacokinetic Tricks and Traps: Drug Dosage Adjustment in Renal Failure. J. Pharm. Pharmaceut. Sci. (www.ualberta.ca/~csps) 2 (1):2-4 (1999).  

Kakkar, T., Boxenbaum, H., Mayersohn, M. Estimation of Ki in a competitive enzyme-inhibition model: Comparisons among three methods of data analysis. Drug Metab Dispos 27: 756-762(1999).

Boxenbaum, H. Cytochrome P450 3A4 In Vivo Ketoconazole Competitive Inhibition: Determination of Ki and Dangers Associated with High Clearance Drugs in General. J. Pharm. Pharmaceut. Sci. (www.ualberta.ca/~csps) 2 (2):45-52 (1999).

Boxenbaum, H. Absorption Potential and its Variants. Pharmaceutical Research 16:1893(1999). 

Boxenbaum, H. Human In vivo competitive inhibition of P450 substrates: Increased plasma concentrations as a function of hepatic extraction ratio and percent inhibition. J. Pharm. Pharmaceut. Sci. (www. ualberta.ca/~csps) 2 (3):89-91 (1999). 

Boxenbaum, H. Commentaries: Does caloric restriction induce hormesis? BELLE (Biological Effects of Low Level Exposures) Newsletter 8:12-13 (2000)

Swenson CE, Bolcsak LE et al. Pharmacokinetics of doxorubicin administered i.v. as Myocet (TLC D-99; liposome-encapsulated doxorubicin citrate) compared with conventional doxorubicin when given in combination with cyclophosphamide in patients with metastatic breast cancer. Anticancer Drugs 14:239-246 (2003)

Harris DS, Boxenbaum H et al. The bioavailability of intranasal and smoked methamphetamine. Clin Pharmacol Ther. 74:475-486 (2003)

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Pharmaceutical - Medical - Biotechnology - Nutraceutical Consulting
Journal Articles
Book Reviews
Books and Monographs
Abstracts
Abstracts

Boxenbaum, H.G., G.S. Jodhka, A.C. Ferguson, S. Riegelman & T. MacGregor.  The influence of bacterial gut hydrolysis on the biopharmaceutics of orally administered isonicotinuric acid in man.  Abstracts of papers presented before the American Pharmaceutical Association  Academy of Pharmaceutical Sciences, 121st A.Ph.A. Annual Meeting, New Orleans, LA., p. 126, April 3 8, 1974. 

Boxenbaum, H.G. & S. Riegelman.  The pharmacokinetics of isoniazid and some metabolites in man.  Abstracts of papers presented before the American Pharmaceutical Association  Academy of Pharmaceutical Sciences, 121st A.Ph.A. Annual Meeting, New Orleans, LA., p. 126, April 38, 1974. 

Boxenbaum, H.G., I. Bekersky, V. Mattaliano & S.A. Kaplan.  Plasma and salivary concentrations of isoniazid in man.  Abstracts of papers presented before the American Pharmaceutical Association  Academy of Pharmaceutical Sciences National Meeting, Atlanta, Georgia, p. 115, November 1620, 1975. 

Boxenbaum, H.G., J. Fellig, L.G. Hanson, W.E. Snyder & S.A. Kaplan.  Pharmacokinetics of sulfadimethoxine in cattle.  Abstracts of papers presented before the American Pharmaceutical Association  Academy of Pharmaceutical Sciences National Meeting, Atlanta, Georgia, p. 126, November 1620, 1975.

Michelson, P.A., W.A. Miller, J.F. Warner, L.W. Ayers and H.G. Boxenbaum.  Multiple dose pharmacokinetics of gentamicin in man: Adjustment of dosage in patients with renal impairment using the Jelliffe nomogram.  Abstracts of papers presented before the American Pharmaceutical Association  Academy of Pharmaceutical Sciences, 123rd A.Ph.A. Annual Meeting, New Orleans, LA., p. 32, April 38, 1976. 

Boxenbaum, H.G., T. Macasieb, R.E. Weinfeld, L. Weissman & S.A. Kaplan.  Biopharmaceutic and pharmacokinetic profile of flunitrazepam following oral administration of single and multiple doses to healthy man.  Abstracts of papers presented before the American Pharmaceutical Association  Academy of Pharmaceutical Sciences National Meeting, Orlando, FL., p. 94, Nov. 1417, 1976.

Eatman, F.B., W.A. Colburn, H.G. Boxenbaum, H.N. Posmanter, R.E. Weinfeld, R. Ronfeld, L. Weissman, J.D. Moore, M. Gibaldi & S.A. Kaplan.  Pharmacokinetics of diazepam following multiple dose oral administration to healthy human subjects.  Abstracts of papers presented before the American Pharmaceutical Association  Academy of Pharmaceutical Sciences, 124th A.Ph.A. Annual Meeting, NY, NY, p. 154, May 1419, 1977.

Eatman, F.B., A.C. Maggio, R. Pocelinko, H.G. Boxenbaum, K.A. Geitner, W. Glover, T. Macasieb, A. Holazo, R.E. Weinfeld & S.A. Kaplan.  Blood and salivary concentrations of trimethoprim and sulfamethoxazole in man.  Abstracts of papers presented before the American Pharmaceutical Association  Academy of Pharmaceutical Sciences, 124th A.Ph.A. Annual Meeting, NY, NY, p. 157, May 1419, 1977. 

Boxenbaum, H.G.  Evolutionary aspects of interspecies variations in pharmacokinetics.  Abstracts of the 2nd Annual Northeastern Regional Pharmaceutical Association Meeting, Storrs, CT., July 10, 1981. 

Boxenbaum, H.G.  Interspecies scaling, allometry, physiological time and the ground plan of pharmacokinetics.  Abstracts of the 2nd Annual Northeastern Regional Pharmaceutical Association Meeting, Storrs, CT, July 10, 1981. 

Boxenbaum, H.G.,  K.A. Geitner, R. Lucek & S. Kaplan.  Interspecies variations in pharmacokinetics:  The benzodiazepines.  Abstracts of the 2nd Annual Northeastern Regional Pharmaceutical Association Meeting, Storrs, CT., July 10, 1981. 

Boxenbaum, H.G.  Interspecies variations in pharmacokinetics: A perspective.  Abstracts of the Sidney Riegelman Memorial Symposium, "Pharmacokinetics: A Modern View,"  San Francisco, CA, April 2224, 1982. 

Ronfeld, R. & H. Boxenbaum.  Allometric adjustments to pharmacokinetic time scales.  Abstracts of the 3rd Annual Northeastern Regional Pharmaceutical Association Meeting, Danbury, CT., June 18, 1982. 

Boxenbaum, H.G.  Fourth dimensional space and the pharmacokinetic spacetime continuum.  Abstracts of the 3rd Annual Northeastern Regional Pharmaceutical Association Meeting, Danbury, CT., June 18, 1982. 

Boxenbaum, H., W. Murray, R. Markin & D. Ciraulo.  Benzodiazepine pharmacokinetics: Clinical highlights, interspecies scaling and structureparameter determinants.  Conference on the Pharmacokinetics and Pharmacodynamics of Psychoactive Drugs, National Institute of Drug Abuse, Bethesda, MD., Feb. 911, 1983.

Boxenbaum, H.  Pharmacokinetic determinants in the design and evaluation of sustainedrelease dosage forms.  Abstracts of the 4th Annual Northeastern Regional Pharmaceutical Association Meeting, Groton, CT, June 17, 1983.

Markin, R.S., W.J. Murray and H. Boxenbaum.  Preliminary QSAR study of human pharmacokinetic parameters of benzodiazepines using the graph theoretical approach.  Abstracts of papers presented before the Academy of Pharmaceutical Sciences National Meeting, Miami Beach, FL, Nov. 1317, 1983. 

Barnhill, J., H. Boxenbaum, D. Greenblatt, R. Smith & D. Ciraulo.  Multiple Dose Alprazolam Kinetics in Panic Disorder Patients.  Abstracts of the 5th Annual Northeastern Regional Pharmaceutical Association Meeting, West Haven, CT, June 22, 1984.   

Boxenbaum, H.G., P.M. Lauven, H.R. Ochs & D.J. Greenblatt.  Midazolam pharmacokinetic profile during and after microprocessor controlled infusion.  Abstracts of the 5th Annual Northeastern Regional Pharmaceutical Association Meeting, West Haven, CT, June 22, 1984. 

MacGregor, T.R., L.P. Gann, F.C. Hiller, F. Hatch and H.G. Boxenbaum.  Human lung absorption of metaproterenol.  Abstracts of the American Pharmaceutical Association  Academy of Pharmaceutical Sciences 39th National Meeting, Minneapolis, Minnesota, Oct. 2024, 1985. 

Boxenbaum, H., C. B. McCullough and F. J. Di Carlo.  Mortality kinetics in toxicity studies. Abstracts of the American Pharmaceutical Association  Academy of Pharmaceutical Sciences 39th National Meeting, Minneapolis, Minnesota, Oct. 2024, 1985. 

Khor, S.P., Wu, H.J. and H. Boxenbaum.  Volume shift and protein leakage corrections for the determination of ligandprotein binding parameter characterization and free fraction estimates from equilibrium dialysis experiments.  Abstracts of the American Pharmaceutical Association  Academy of Pharmaceutical Sciences 39th National Meeting, Minneapolis, Minnesota, Oct. 2024, 1985.

Boxenbaum, H.  Time concepts in physics, biology and pharmacokinetics.  Abstracts of papers presented before the American Pharmaceutical AssociationAcademy of Pharmaceutical Sciences, 133rd A.Ph.A. Annual Meeting, San Francisco, CA, March 1620, 1986. 

Thompson, G.A., H. Boxenbaum, F.J. Keeley, J.D. Theile & R.A. Okerholm.  Absorption and disposition of piroximone (MDL 19205) in congestive heart failure patients.  Abstracts of papers presented before the American Association of Pharmaceutical Scientists, First National Meeting, Washington, D.C., Nov. 26, 1986 (Pharm. Res. 3 [No. 5, Oct. Supplement]: 106S (1986).

Neafsey, P.J., H. Boxenbaum, D. Ciraulo & D.J. Fournier.  Toxicokinetic doseresponse models of mortality in toxicity studies.  Abstracts of papers presented before the American Association of Pharmaceutical Scientists, First National Meeting, Washington, D.C., Nov. 26, 1986 (Pharm. Res. 3 [No. 5, Oct. Supplement]: 136S (1986)).

Boxenbaum, H., F. Pivinski & S.J. Ruberg.  Publication rates of pharmaceutical scientists: Application of the Waring distribution.  Abstracts of papers presented before the American Association of Pharmaceutical Scientists, First National Meeting, Washington, D.C., Nov. 26, 1986 (Pharm. Res. 3 [No. 5, Oct. Supplement]: 136S (1986)).

Boxenbaum, H. Biopharmaceutical, Physiological and Pharmacokinetic Determinants in the Design and Evaluation of SustainedRelease Dosage Forms.  Abstracts of papers presented before the American Association of Pharmaceutical Scientist's Midwest Regional Meeting, Chicago, Illinois, May 18, 1987.

Boxenbaum, H. & D'Souza, R. The Reductionist and Allometric Paradigms of Interspecies Pharmacokinetic Scaling. Abstracts of papers presented before the 47th International Congress of Pharmaceutical Sciences of F.I.P., Amsterdam, Aug. 31Sept. 4, 1987 (Int. Pharmacy J. (Suppl. 1), 1987, p. S5). 

Boxenbaum, H. & D'Souza, R.W. Pharmacokinetic ScaleUp from Animal to Man. Abstracts of papers presented before the Troisiemes Journees Mediterraneennes de Pharmacocinetique, Cap d'Agde, France, May 1921, 1988.   

Hook, R.H., Boxenbaum, H., Thompson, G.A. & Okerholm, R.A. Human serum and plasma protein binding of enoximone and its sulfoxide metabolite.  Abstracts of papers presented before the American Association of Pharmaceutical Scientist's Third Annual Meeting and Exposition, Orlando, Florida, October 30  November 3, 1988, Pharmaceutical Res., Vol 5, No. 10, Oct. 1988 (Supplement), p. S 215. 

Greenblatt, D.J., Divoll, M.K., Soong, M.H., Boxenbaum, H.G., Harmatz, J.S. & Shader, R.I. Extent of metabolic conversion of diazepam to desmethyldiazepam.  Abstracts of papers: American College of Clinical Pharmacology Meeting, Orlando, FL, Oct 30  Nov 3, 1988.

Boxenbaum, H. Interspecies pharmacokinetic scaling. Abstracts of the Czechoslovak Medical Society Symposium on Compartmental and Noncompartmental Modeling in Pharmacokinetics, Smolenice Castle, Czechoslovakia, Sept. 1216, 1988. 

Boxenbaum, H., Gillespie, T., Heck, K. & Hahne, W.F. Pharmacokinetics (PK) of a new serotonin 5HT3 receptor antagonist, MDL 73,147EF. Abstracts of the 93rd annual meeting of the Am. Soc. Clin. Pharmacol. Ther., Orlando, FL, March 1820, 1992; also published in Clin. Pharmacol. Ther. 51:131 (1992).

Boxenbaum, H. NSAID pharmacokinetic-pharmacodynamic relationships with respect to synovial fluid.  Abstracts of the Seventh Annual Clinical Update in Rheumatology, Phila, PA, Nov. 9-12, 1992. 

Meng, X, Parker, V, Turner, M, Hicks, D, Boxenbaum, H and Chiang, S. Effect of tolrestat (T) on pharmacokinetics (PK) and pharmacodynamics (PD) of warfarin (W). The ASCPT 95th Annual Meeting, New Orleans, LA, March, 1994.

Tata, P., Boxenbaum, H. & Bramer, S. Proposed guidelines for validating serum and plasma protein binding utilizing ultrafiltration: Case studies with investigational drugs.  American Association of Pharmaceutical Scientist's Annual Meeting and Exposition, Seattle, WA, October 27  October 31, 1996. 

Tannenbaum, S., Boxenbaum, H. & Mayersohn, M. Allometric analysis of organ extraction ratios. American Association of Pharmaceutical Scientist's Annual Meeting and Exposition, Boston, Nov 2-6, 1997 (Published in: Pharm. Res. 14 (11), Nov. 1997 (Supplement), p. S-242.).

Kakkar, T. S., Boxenbaum, H. and Mayersohn, M. Estimation of Ki in a competitive enzyme-inhibition model.  Comparisons among three methods of data analysis. American Association of Pharmaceutical Scientist's Annual Meeting and Exposition, San Francisco, Nov. 15-19, 1998. 

Pak, Y., Kakkar, T.S., Boxenbaum, H. and Mayersohn, M. Estimation of Ki in a competitive enzyme-inhibition model. Evaluation of a minimal experimental design. American Association of Pharmaceutical Scientist's Annual Meeting and Exposition, San Francisco, Nov. 15-19, 1998. 

Boxenbaum, H. Allometric Principles. American Association of Pharmaceutical Scientist's Annual Meeting and Exposition, In: Short Course entitled: Interspecies Scaling: Techniques, Concepts and Considerations," November 15, 1998. 

Boxenbaum, H, Muenz, LR & Estrasorb Study Group. Pharmacokinetics of ESTRASORB, a topical lotion for treatment of postmenopausal vasomotor symptoms. Scientific Program and Abstracts, 49th Annual Meeting, March 20-23, 2002, Los Angeles, CA, Society for Gynecologic Investigation,  published in Supplement to Journal of the Society for Gynecologic Investigation, 9(1), Supplement, January/February, 2002, Abstract Number 533.

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Book Reviews

Thompson, G.A. and H. Boxenbaum. Drug Dynamics for Analytical, Clinical, and Biological Chemists. By B.J. Gudzinowicz, B.T. Younkin, Jr., and M.J. Gudzinowicz. Marcel Dekker, Inc., N.Y., 1984. Review published in J. Pharm. Sci. 74: 11411142 (1985).

Boxenbaum, H. Development of Drugs and Modern Medicines: A Conference to Honor Professor Arnold H. Beckett. Edited by J.W. Gorrod, G.G. Gibson and M. Mitchard. VCH Verlagsgesellschaft, Weinheim, Federal Republic of Germany, 1986. Review published in J. Pharm. Sci. 76: 502 (1987). 

Boxenbaum, H. Antiepileptic Drugs, 3rd ed. Edited by R.H. Levy, F.E. Dreifuss, R.H. Mattson, B.S. Meldrum & J.K. Penry. Raven Press, N.Y., 1989. Review published in J. Pharm. Sci. 79:657 (1990).

Boxenbaum, H. Drug Toxicokinetics. Edited by P.G. Welling and F. A. de la Iglesia. Marcel Dekker, N.Y., 1993. Review published in Drug Metabolism Reviews, 25:521 (1993).

Boxenbaum, H. Mathematical Modelling of Pharmacokinetic Data. By David W.A. Bourne, Technomic Publishing Co., Lancaster, PA, 1995.  Review published in International Society for the Study of Xenobiotics (ISSX) Newsletter, Volume 15/Issue #2, 1996, p. 9. 


Books and Monographs

Michelson, P.A., W.A. Miller, J.F. Warner, L.W. Ayers and H.G. Boxenbaum. Multiple dose pharmacokinetics of gentamicin in man: Evaluation of the Jelliffe nomogram and the adjustment of dosage in patients with renal impairment. In: The Effects of Disease States on Drug Pharmacokinetics, L. Z. Benet, Ed., Amer. Pharm. Assoc., Wash., D.C., 1976, Chap. 12, pp. 207245.

Boxenbaum, H. and R. Ronfeld. Interspecies variations in pharmacokinetics: A perspective. In: Pharmacokinetics: A Modern View, L.Z. Benet, G. Levy & B.L. Ferraiolo, Eds., Plenum Press, N. Y., 1984, pp. 438441.

Boxenbaum, H., W. Murray, R. Markin and D. Ciraulo. Benzodiazepine  pharmacokinetics: Clinical highlights and interspecies scaling. In: Pharmacokinetics and Pharmacodynamics of Psychoactive Drugs, G. Barnett and C.N. Chiang, Eds., Biomedical Publications, Foster City, CA, 1985, Chap. 5, pp. 93 119. 

Boxenbaum, H. and D'Souza, R. Interspecies Pharmacokinetic Scaling: Reductionist and Allometric Paradigms. In: Topics in Pharmaceutical Sciences 1987, D. D. Breimer & P. Speiser, Eds., Elsevier Science Publishers, Amsterdam, 1987, pp. 4962. 

Boxenbaum, H and D'Souza, R. Physiological Models, Allometry, Neoteny, SpaceTime and Pharmacokinetics. In: Pharmacokinetics, A. Pecile and A. Rescigno, Eds., Plenum Publishing Co., London, 1988, pp. 191214.

Boxenbaum, H. and D'Souza, R.W. Pharmacokinetic ScaleUp from Animal to Man. In: Interet et Limites de la Pharmacocinetique en Recherche et developpement, J. Bres and G. Panis, Eds., Sauramps Medical, Montpellier, 1988, pp. 135. 

Pang, K.S. and Boxenbaum, H. Pharmacokinetic Scaling from Animals to Man: Basic Concepts. In: Xenobiotic Metabolism and Disposition, R. Kato, R.W. Estabrook and M.N. Cayen, Eds., Taylor & Francis, London, 1989, pp. 237244. 

Boxenbaum, H. & D'Souza, R.W. Interspecies Pharmacokinetic Scaling, Biological Design and Neoteny. In: Advances in Drug Research, Vol. 29, B. Testa, ed., Academic Press, London, 1990, pp. 139196. 

Boxenbaum, H. Allometric scaling and drug dosage. In: Toxicology Forum: 1990 Annual Summer Meeting, Toxicology Forum, Inc., Wash., D.C., 1990, pp. 378392.

Boxenbaum, H. Hypotheses on mammalian aging, toxicity and longevity hormesis: Explication by a generalized Gompertz function. In: Biological Effects of Low Level Exposures to Chemicals and Radiation, E.J. Calabrese, ed., Lewis Publishers, Boca Raton, 1992, Chapter 1, pp. 139.

Boxenbaum, H. Interspecies scaling: Desultory reflections. In: Pharmacokinetic / Pharmacodynamic Analysis: Accelerating Drug Discovery and Development. J. Schlegel, ed., International Business Communications, Inc., Southborough, MA, 1996, Chapter 2.6, pp. 2.6.1 - 2.6.11. 

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